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The immature platelet fraction (IPF) - The first to know about megakaryocyte activity
Megakaryocytes pinch off reticulated platelets which develop into mature platelets within one or two days. An indication for the rate of thrombopoiesis is the amount of reticulated platelets found in peripheral blood. It is now possible to investigate the utility of the immature platelet fraction with a routine haematology analyser.
The immature platelet fraction (IPF) in neonates
Thrombocytopenia occurs in 30% of all neonates admitted to intensive care. Young, immature platelets containing RNA, measured as “immature platelet fraction” (IPF) on Sysmex analyzers, can help to assess platelet production. Thus, they allow conclusions on both the etiology and the likely course of thrombocytopenia in neonates.
The importance of thrombocytopenia and its causes
Thrombocytopenia is a disorder in which there is an abnormally low amount of platelets. It can be life threatening and its detection and precise count is extremely important. The immature platelet fraction (IPF parameter) measures young, reticulated platelets in peripheral Blood, revealing if the bone marrow is producing or not.
- Diagnosztikai perspektívák
Usefulness of neut-x determination in routine diagnostic procedures: application to myelodysplastic syndromes
Myelodysplastic syndromes (MDS) often go unnoticed when only a complete blood count is performed on the patient. Sysmex X-Class analysers can measure the granularity of leukocytes which is often reduced in MDS. NEUT-X, the measure of neutrophil granularity, is an excellent tool to filter samples suspected of MDS in anaemic patients.
- White Paper
White blood cell functionality
By combining the WDF and WPC channels both the sensitivity and specificity for detecting reactive and malignant cells is optimised. The measurement technology of XN-Series analysers detects the white blood cell functionality and the novel ‘Extended Inflammation Parameters’ let you quantify activated lymphocytes and neutrophils, and the results can be applied once a malignancy has been excluded.